Miltenyi Biotech, Cologne
Andreas Bosio
Miltenyi Biotec GmbH is the leading enterprise world-wide in the magnetic bead-based cell separation technologies (rating of Deutsche Bank according to Standard&Poors: iBBB+). Miltenyi Biotec develops, produces and markets more than 700 state-of-the-art products and services for cell separation (MACS®), cell analysis, cell culture, molecular biology, and clinical research applications. The MACS Technology combines the use of MACS MicroBeads (50 nm superparamagnetic particles coupled to specific antibodies), MACS Columns and MACS Separators to obtain enriched cell populations. The molecular analysis branch of Miltenyi Biotec, MACSmolecular (formerly Memorec Biotec), has 10 years experience in the design, production, quality control, and data analysis of microarrays. It has also established transgenic and gene targeting technologies and is equipped with a barrier breeding facility to accommodate up to 8000 mice under pathogen-free conditions (SPF).
Training and transfer of knowledge environment
At Miltenyi Biotec GmbH we have an undergraduate/graduate program currenty including 11 PhDs and 4 undergraduate students. PhD students are always trained in collaboration with German universities or Max Planck institutes (e.g. Cologne, Bonn, Witten, Essen) and, therefore, they participate in the regular PhD program of the respective Universities.
Andreas Bosio Head of R&D MACSMolecular transcriptomics, mouse genetics
Serena Barral experienced researcher Embryonic Stem Cell Research
Selected Publications
1. Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst A.O., Landthaler M., Lin C., Socci N.D., Hermida L., Fulci F., Schliwka J., Fuchs U., Novosel A., Müller R-U., Schermer B., Bissels U., Inman J., Phan Q., ; Chien M., Weir D.B., Choksi R., De Vita G., Frezzetti D., Trompeter H-I., Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P., Macino G., Rogler C.E., Nagle J.W., Ju J., Papavasiliou N., Benzing T., Lichter P., Tam W., Brownstein M.J., Bosio A., Borkhardt A., Russo J.J., Sander C., Zavolan M., Tuschl T. (2007) A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing. Cell, submitted.
2. Baumann C, Korner R, Hofmann K, Nigg EA. (2007) PICH, a centromere-associated SNF2 family ATPase, is regulated by Plk1 and required for the spindle checkpoint. Cell. 128, 101-14.
3. Niewoehner B, Single FN, Hvalby O, Jensen V, Borgloh SM, Seeburg PH, Rawlins JN, Sprengel R, Bannerman DM. (2007) Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus. Eur J Neurosci. 25:837-46.
4. Seidenfaden R., Desoeuvre A., Bosio A., Virard I., Cremer H. (2006) Glial conversion of SVZ-derived committed neuronal precursors after ectopic grafting into the adult brain. Mol Cell Neurosci. 32, 187-98.
