Harold Cremer

Developmental Biology Institute of Marseille

The Developmental Biology Institute of Marseille is a highly ranked research institute of the French CNRS and the University of Marseille. It comprises 24 groups including 9 working on different aspects of neurobiology and neural development. The Institute provides state-of-the-art transgenic, informatics and imaging services partly in common with the neighbouring Centre d’Immunologie de Marseille Luminy.
The group of Harold Cremer (Research Director in the CNRS) made over the past decade important contributions to our understanding of the molecular cues regulation cell communication during neurogenesis and neuronal function. The group is implicated in close interactions with the company Miltentyi  and performed the first genome wide expression analysis of adult neuronal precursors.

Training and transfer of knowledge environment
The graduate school of the University Aix-Marseille 2 is based on 70 research laboratories comprising about 500 scientists that are habilitated to teach PhD students. It has been created in 1999 and is therefore one of the oldest graduate schools in France. Its flow through of PhDs is in the range of 100 per year.

Harold Cremer         Research Director, Group Leader    Mouse genetics, neuroanatomy

Marie-C. Tiveron    Staff Scientist                Mouse genetics, neuroanatomy
Simone Diestel        Postdoc                Cell biology, Molecular Biology
Camille Boutin        PhD Student                Brain electroporation in vivo
Angelique Desoeuvre    Technician                Brain electroporation in vivo

Selected Publications
Gheusi, G., Cremer, H., McLean, H., Chazal, G., Vincent, J. D., and Lledo, P. M. (2000). Importance of newly generated neurons in the adult olfactory bulb for odor discrimination. Proc Natl Acad Sci U S A 97, 1823-1828.
Hack, I., Bancila, M., Loulier, K., Carrol, P., Cremer, H. (2002) Reelin is a detachment  signal in tangential cell migration during adult neurogenesis. Nature Neuroscience 5, 939-945
Pennartz, S., Bevindrah, R., Tomiuk, S., Zimmer, C., Hofmann, K., Conrad, M., Bosio, A., Cremer, H. (2004) Purification of neuronal precursors from the adult brain: comprehensive analysis of gene expression provides new insights into the control of cell migration, differentiation and homeostasis. Mol Cell Neurosci 25, 692-706
Tiveron, MC, Rossel, M., Moepps, B., Zhang, Y.L., Seidenfaden, R., Favor, J., König, N., and Cremer, H., Molecular interaction between projection neuron precursors and invading interneurons via SDF-1(CXCL12)/CXCR4 signalling in the cortical SVZ/IZ, 2006, J. Neurosci, 26(51):13273-8